Epidemiologic Characteristics and Natural History of HIV-1 Natural Viral Suppressors
نویسندگان
چکیده
منابع مشابه
Natural history of HIV-1 infection.
Infection with the human immunodeficiency virus type 1 (HIV-1) results in progressive loss of immune function marked by depletion of the CD4+ T-lymphocytes, leading to opportunistic infections and malignancies characteristic of AIDS. Although both host and viral determinants influence the rate of disease progression, the median time from initial infection to the development of AIDS among untrea...
متن کاملChronic immune activation and decreased CD4 cell counts associated with hepatitis C infection in HIV-1 natural viral suppressors.
We have established a cohort of natural viral suppressors (NVS) who can suppress HIV-1 replication to less than 400 copies/ml in the absence of therapy (similar to Elite Controllers/Elite Suppressors). Of the 59 patients currently in the NVS cohort, 45.8% have chronic hepatitis C virus (HCV) infection, thereby presenting a unique opportunity to study immune activation and the interaction betwee...
متن کاملThe natural history of HIV infection
PURPOSE OF REVIEW To review recent published literature around three areas: long-term nonprogression/viral control; predictors of viral load set point/disease progression; and the potential impact of antiretroviral therapy (ART) in early HIV infection. RECENT FINDINGS The natural course of untreated HIV infection varies widely with some HIV-positive individuals able to maintain high CD4 cell ...
متن کاملAcute Hepatitis C Infection in HIV Co-infection - Epidemiology, Natural History and the Host-viral Responses
Aim: To analyse the epidemiological, clinical and immunological aspects of a recent epidemic of acute HCV in HIV co-infected individuals. Methods: The epidemiology was characterised using combined molecular and clinical studies. A phylogenetic analysis of the E1/E2 region of the HCV genome was performed to determine HCV transmission. Transmission risk factors were then explored in a multicentre...
متن کامل[Natural history of type 1 diabetes].
The natural history of autoimmune type 1 diabetes in children is associated with the appearance of islet autoantibodies early in life, which is influenced by genetic and environmental factors. Once islet autoantibodies have developed, the progression to diabetes in antibody-positive individuals is determined by the age of antibody appearance and by the magnitude of the autoimmunity, in turn rel...
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ژورنال
عنوان ژورنال: JAIDS Journal of Acquired Immune Deficiency Syndromes
سال: 2009
ISSN: 1525-4135
DOI: 10.1097/qai.0b013e3181945f1e